Spirit said:
The watches are designed to be easily operated with your "main" hand. as a destro, you would like to operate the crown and or pushers with the hand you have more ability with. That´s why they´re in the right side of the case. If they were in the left size of the case, you would have only your right thumb to operate it and it would not be comfortable.(that´s for pushing buttons)
Once I hurt my wrist while racing a go-kart.
...I was wearing my Rolex Datejust while driving (Thanks it was not a Daytona or a Submariner), and the funky groove on the track made it shake too much, taking some scalps of my skin. Due to this hurting, I wasn´t able to wear my watch in the left wrist, so started wearing it on the right one, and it´s indeed awful, for me.
I thought that Destros were also meant to be worn on the left wrist when you want a smooth side to be towards your hand (protecting both your hand and the watch)... that way: no extra weight for right-handed folks on their right wrist, and little risk for injury or watch damage.